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Sodium Hydroxide → tert-butyl (1-(4-(5-(2,6-difluorophenyl)-1H-indol-3-yl)-6-methoxypyrimidin-2-yl)piperidin-4-yl)carbamate

HRID 1529419
ノート
印刷プレビュー

反応式

HRID 1529419 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14](S(C1C=CC(C)=CC=1)(=O)=O)[CH:13]=[C:12]2[C:28]1[CH:33]=[C:32]([O:34][CH3:35])[N:31]=[C:30]([N:36]2[CH2:41][CH2:40][CH:39]([NH:42][C:43](=[O:49])[O:44][C:45]([CH3:48])([CH3:47])[CH3:46])[CH2:38][CH2:37]2)[N:29]=1.[OH-].[Na+]>O1CCOCC1>[F:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[C:3]=1[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]=[C:12]2[C:28]1[CH:33]=[C:32]([O:34][CH3:35])[N:31]=[C:30]([N:36]2[CH2:41][CH2:40][CH:39]([NH:42][C:43](=[O:49])[O:44][C:45]([CH3:47])([CH3:46])[CH3:48])[CH2:38][CH2:37]2)[N:29]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 86709789tert-butyl (1-(4-(5-(2,6-difluorophenyl)-1-tosyl-1H-indol-3-yl)-6-methoxypyrimidin-2-yl)piperidin-4-yl)carbamate

生成物 1

HCID 67976781tert-butyl (1-(4-(5-(2,6-difluorophenyl)-1H-indol-3-yl)-6-methoxypyrimidin-2-yl)piperidin-4-yl)carbamate収率 54%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a solution of tert-butyl (1-(4-(5-(2,6-difluorophenyl)-1-tosyl-1H-indol-3-yl)-6-methoxypyrimidin-2-yl)piperidin-4-yl)carbamate (60 mg, 0.087 mmol) in dioxane (0.8 mL) was added 7M aq.NaOH (1 mL) and the mixture was heated at 90° C. for 6 h. The reaction was quenched with water and the suspension was filtered. The resulting solid was washed with water and dried. The crude was purified with basic alumina chromatography to give tert-butyl (1-(4-(5-(2,6-difluorophenyl)-1H-indol-3-yl)-6-methoxypyrimidin-2-yl)piperidin-4-yl)carbamate (25 mg, 54%). 1H-NMR (300 MHz, DMSO-d6): δ 11.80 (brs, 1H), 8.58 (s, 1H), 8.26 (s, 1H), 7.40-7.55 (m, 2H), 7.18-7.26 (m, 4H), 6.85 (d, J=7.5 Hz, 1H) 6.49 (s, 1H), 4.66 (d, J=11.7 Hz, 2H), 3.84 (s, 3H), 3.52 (brs, 2H), 2.97-3.05 (m, 2H), 1.7 (brs, 2H), 1.38 (s, 9H).

後処理

  1. customThe reaction was quenched with water
  2. filtrationthe suspension was filtered
  3. washThe resulting solid was washed with water
  4. customdried
  5. customThe crude was purified with basic alumina chromatography

出典と根拠

ORDレコード
ord-6ca24a7f13534057b8f29f013ef7b1db
出典データセット
uspto-grants-2015_07
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09090593B2

反応ノート

読み込み中…

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