Potassium Carbonate → 2-Decylsulfonyl-4-pyrrolidinonitrobenzene

HRID 1530785ノート

反応式

HRID 1530785 の反応式
[CH2:1]([S:13]([C:16]1[CH:21]=[C:20](Cl)[CH:19]=[CH:18][C:17]=1[N+:23]([O-:25])=[O:24])(=[O:15])=[O:14])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10]CC.[NH:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1.C(=O)([O-])[O-].[K+].[K+].CC(N(C)C)=O>O>[CH2:1]([S:13]([C:16]1[CH:21]=[C:20]([N:26]2[CH2:30][CH2:29][CH2:28][CH2:27]2)[CH:19]=[CH:18][C:17]=1[N+:23]([O-:25])=[O:24])(=[O:14])=[O:15])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

参加物

6

反応物 4

HCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 31374DimethylacetamideHCID 183562922-Dodecylsulfonyl-4-chloronitrobenzene

生成物 1

HCID 212526452-Decylsulfonyl-4-pyrrolidinonitrobenzene収率 45.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
90 °C

実験手順

A mixture of 27.5 g of 2-dodecylsulfonyl-4-chloronitrobenzene, 5.5 g of pyrrolidine, 138 g of potassium carbonate and 70 ml of dimethylacetamide was stirred for 3 hours at 90° C. To this reaction mixture was added 210 ml of water, and the precipitated crystal was collected by filtration and recrystallized with acetonitrile to obtain 12.7 g of 2-decylsulfonyl-4-pyrrolidinonitrobenzene.

後処理

  1. filtrationthe precipitated crystal was collected by filtration
  2. customrecrystallized with acetonitrile

出典と根拠

ORDレコード
ord-18e75f44964048e0bd72911995e12328
出典データセット
uspto-grants-2001_03
特許番号
US06197725B1

反応ノート

読み込み中…