Diethyl 2-(4-(benzyloxy)phenyl)malonate → Dimethyl (4-hydroxyphenyl)malonate

HRID 1530809

反応式

HRID 1530809 の反応式
[H][H].C([O:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]([C:23]([O:25][CH2:26]C)=[O:24])[C:18]([O:20][CH2:21]C)=[O:19])=[CH:13][CH:12]=1)C1C=CC=CC=1>CO.[Pd]>[OH:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]([C:23]([O:25][CH3:26])=[O:24])[C:18]([O:20][CH3:21])=[O:19])=[CH:13][CH:12]=1

参加物

5

反応物 2

HCID 2823246Diethyl 2-(4-(benzyloxy)phenyl)malonateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 3018973Dimethyl (4-hydroxyphenyl)malonate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

At room temperature and a hydrogen pressure of 5 bar, 94.3 g of diethyl (4-benzyloxyphenyl)malonate (J. Org. Chem. 46, 3007 (1981)) in 500 ml of methanol were hydrogenated in the presence of 5 g of palladium/carbon catalyst (5%). The catalyst was filtered off and the mixture was concentrated, to give the title product as a colourless oil.

後処理

  1. customAt room temperature
  2. filtrationThe catalyst was filtered off
  3. concentrationthe mixture was concentrated

出典と根拠

ORDレコード
ord-77406f95a9a6483b881a31d1e265654e
出典データセット
uspto-grants-2001_03
特許番号
US06197729B1

関連ノート

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