Benzylamine → HCID 178520974、化合物

HRID 1530819ノート

反応式

HRID 1530819 の反応式
[H][H].[OH:3][CH:4]([CH:9]1[CH2:14][CH2:13][C:12](=O)[CH2:11][CH2:10]1)[C:5]([F:8])([F:7])[F:6].[CH2:16]([NH2:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>CO.[Pt]>[CH2:16]([NH:23][C@H:12]1[CH2:13][CH2:14][C@@H:9]([CH:4]([OH:3])[C:5]([F:8])([F:7])[F:6])[CH2:10][CH2:11]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

6

反応物 3

HCID 7504BenzylamineHCID 212527094-(1-Hydroxy-2,2,2-trifluoroethyl)cyclohexanoneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 178520974HCID 178520974、化合物

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 887Methanol溶媒

実験手順

At 50° C. and a hydrogen pressure of 5 bar, 43.0 g of 4-(1-hydroxy-2,2,2-trifluoroethyl)cyclohexanone and 24.0 g of benzylamine in 400 ml of methanol were hydrogenated in the presence of 1.5 g of platinum (5% on carbon). The catalyst was filtered off and the mixture was concentrated. The cis/trans isomers were separated by silica gel chromatography (ethyl acetate/ethanol 9:1). The cis isomer eluted first of the two isomers, to give the title product as a colourless oil.

後処理

  1. customAt 50° C.
  2. filtrationThe catalyst was filtered off
  3. concentrationthe mixture was concentrated
  4. customThe cis/trans isomers were separated by silica gel chromatography (ethyl acetate/ethanol 9:1)
  5. washThe cis isomer eluted first of the two isomers

出典と根拠

ORDレコード
ord-edf21f0f2d414549adc75e0ba890257b
出典データセット
uspto-grants-2001_03
特許番号
US06197729B1

反応ノート

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