Sodium Hydroxide → 10-bromo-5-carboxy-2-methoxy-4H-pyrido[3,2,1-jk]carbazole-4-one

HRID 1530982ノート

反応式

HRID 1530982 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]3[CH:19]=[C:18]([C:20]([O:22]CC)=[O:21])[C:17](=[O:25])[C:8]4[CH:9]=[C:10]([O:15][CH3:16])[CH:11]=[C:12]([C:13]=2[CH:14]=1)[C:7]3=4.[OH-].[Na+]>C(O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]3[CH:19]=[C:18]([C:20]([OH:22])=[O:21])[C:17](=[O:25])[C:8]4[CH:9]=[C:10]([O:15][CH3:16])[CH:11]=[C:12]([C:13]=2[CH:14]=1)[C:7]3=4

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 2125285710-bromo-5-ethoxycarbonyl-2-methoxy-4H-pyrido [3,2,1-jk]carbazole-4-one

生成物 1

HCID 2125282410-bromo-5-carboxy-2-methoxy-4H-pyrido[3,2,1-jk]carbazole-4-one収率 83.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

10-bromo-5-ethoxycarbonyl-2-methoxy-4H-pyrido[3,2,1-jk]carbazole-4-one (400 mg) obtained in Example 98 was suspended in ethanol (10 ml), and 1N sodium hydroxide (3 ml) was added. The mixture was stirred at room temperature for 12 hours, and the solvent was evaporated under reduced pressure. To tne residue was added IN hydrochloric acid to pH 1, and the crystals precipitated were recovered by filtration, and washed with ethanol and ether to obtain the title compound (310 mg, 83%).

後処理

  1. customthe solvent was evaporated under reduced pressure
  2. additionTo tne residue was added IN hydrochloric acid to pH 1
  3. customthe crystals precipitated
  4. filtrationwere recovered by filtration
  5. washwashed with ethanol and ether

出典と根拠

ORDレコード
ord-bfb4ac67bb4f447b968cfcccf2e5a4ef
出典データセット
uspto-grants-2001_03
特許番号
US06197768B1

反応ノート

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