HCID 15385778、化合物 → 3-Cyclohexyl-N-(ethanesulfonyl)-D-alanyl-L-proline
反応式
[CH2:1]([S:3]([NH:6][C@@H:7]([C:15]([N:17]1[CH2:24][CH2:23][CH2:22][C@H:18]1[C:19]([OH:21])=[O:20])=[O:16])[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:5])=[O:4])[CH3:2]>C(O)C.O=[Pt]=O>[CH2:1]([S:3]([NH:6][C@@H:7]([C:15]([N:17]1[CH2:24][CH2:23][CH2:22][C@H:18]1[C:19]([OH:21])=[O:20])=[O:16])[CH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)(=[O:5])=[O:4])[CH3:2]参加物
4
実験手順
To a solution of EtSO2-D-Phe-Pro-OH (10 g, 28 mmol) in ethanol (300 mL) was added PtO2 (5 g). The mixture was hydrogenated using a high pressure apparatus at 4.1 bar and 20° C. for 20 h. The solution was then filtered through diatomaceous earth, and concentrated to give 8.1 g (80%) of thick oil.