Ethanol → 3-[(3,5-Dimethylphenyl)amino]propanoic acid

HRID 1531985ノート

反応式

HRID 1531985 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([CH3:13])[CH:12]=1)[NH:5][CH2:6]CC#N.[OH-:14].[Na+].[CH2:16]([OH:18])[CH3:17]>O>[CH3:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([CH3:13])[CH:12]=1)[NH:5][CH2:6][CH2:17][C:16]([OH:14])=[O:18]

参加物

5

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 2926323-[(3,5-Dimethylphenyl)amino]propanenitrile

生成物 1

HCID 24348423-[(3,5-Dimethylphenyl)amino]propanoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

β-(3,5-Dimethylanilino)propionitrile (4.5 g) was dissolved in ethanol (50 ml), and a solution of NaOH (5.1 g) in water (25 ml) was added, which was followed by refluxing for 4 hr. The solvent was evaporated under reduced pressure. 2N Hydrochloric acid was added to adjust the residue acidic, and the mixture was washed with chloroform (100 ml). The aqueous layer was concentrated to about 20 ml and allowed to stand. The precipitated crystals were collected by filtration and dried to give 4.0 g of β-(3,5-dimethylanilino)propionic acid.

後処理

  1. temperatureby refluxing for 4 hr
  2. customThe solvent was evaporated under reduced pressure
  3. addition2N Hydrochloric acid was added
  4. washthe mixture was washed with chloroform (100 ml)
  5. concentrationThe aqueous layer was concentrated to about 20 ml
  6. filtrationThe precipitated crystals were collected by filtration
  7. customdried

出典と根拠

ORDレコード
ord-a255f76d6b4f4bff9e161139272c3390
出典データセット
uspto-grants-2001_03
特許番号
US06200988B1

反応ノート

読み込み中…