1,1'-Carbonyldiimidazole → 2-Chloro-3-fluoro-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide

HRID 1532309ノート

反応式

HRID 1532309 の反応式
[Cl:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.C(N1C=CN=C1)(N1C=CN=C1)=O.[C:24]12([CH2:34][NH2:35])[CH2:33][CH:28]3[CH2:29][CH:30]([CH2:32][CH:26]([CH2:27]3)[CH2:25]1)[CH2:31]2>CN(C)C=O>[Cl:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:35][CH2:34][C:24]12[CH2:33][CH:28]3[CH2:27][CH:26]([CH2:32][CH:30]([CH2:29]3)[CH2:31]1)[CH2:25]2)=[O:6]

参加物

5

反応物 3

HCID 682631,1'-CarbonyldiimidazoleHCID 86625Tricyclo(3.3.1.13,7)dec-1-ylmethylamineHCID 3026202-Chloro-3-fluorobenzoic acid

生成物 1

HCID 206700332-Chloro-3-fluoro-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 2-chloro-3-fluorobenzoic acid (0.098 g) and carbonyldiimidazole (0.091 g), in N,N-dimethylformamide (3.0 ml) was stirred for 2.5 hours at room temperature. 1-Adamantanemethylamine (0.1 ml) was then added and stirring continued overnight. The reaction mixture was partitioned between ethyl acetate and 2N hydrochloric acid and the organic layer was separated, washed with 10% aqueous sodium hydroxide, water and brine and then dried over sodium sulphate (Na2SO4). The organic layer was subsequently concentrated under reduced pressure to yield the title compound as a white solid (0.138 g).

後処理

  1. customThe reaction mixture was partitioned between ethyl acetate and 2N hydrochloric acid
  2. customthe organic layer was separated
  3. washwashed with 10% aqueous sodium hydroxide, water and brine
  4. dry with materialdried over sodium sulphate (Na2SO4)
  5. concentrationThe organic layer was subsequently concentrated under reduced pressure

出典と根拠

ORDレコード
ord-6c75761268064efebe7add7541786ba6
出典データセット
uspto-grants-2001_03
特許番号
US06201024B1

反応ノート

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