Water → 2-(2,4-Diaminophenoxy)ethanol

温度

20 °C

A 1 l autoclave reactor was filled with 120 g of 2-(2′,4′-dinitrophenoxy)ethanol, 3 g of a 1% platinum/carbon catalyst which included 50% water, and 400 ml of isopropanol. At a hydrogen pressure of 1 MPa and a temperature of 100° C., hydrogenation was carried out for 10 h. The system was then cooled to 20° C., and the reaction mixture was added dropwise under a nitrogen atmosphere through a filter into an initial charge of 240 g of 37% strength hydrochloric acid which had been previously flushed repeatedly with nitrogen. The resulting suspension was heated at reflux temperature for about 30 min and then cooled to 10° C. The product obtained after filtration was washed once with isopropanol to give 113.1 g of 2-(2′,4′-diamino-phenoxy)ethanol (89.1% yield) in 98% purity. Measuring the degrees of transmission of a 0.1% strength solution of the product in water in accordance with DIN 55945 gave, as results, Tx=99.4, Ty=98.9 and Tz=98.2.

1. additionthe reaction mixture was added dropwise under a nitrogen atmosphere through
2. filtrationa filter into
3. additionan initial charge of 240 g of 37% strength hydrochloric acid which
4. customhad been previously flushed repeatedly with nitrogen
5. temperatureThe resulting suspension was heated
6. temperatureat reflux temperature for about 30 min
7. temperaturecooled to 10° C
8. customThe product obtained
9. filtrationafter filtration
10. washwas washed once with isopropanol

ORDレコード

ord-0043d53f073245c48ba7e87bdd1f2096

出典データセット

uspto-grants-2001_03

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06204413B1