HCID 86756551、化合物 → HCID 22011772、化合物
反応式
C[O:2][C:3](=[O:27])/[C:4](/[CH:10]([P:19]([O:24][CH2:25][CH3:26])([O:21][CH2:22][CH3:23])=[O:20])[P:11]([O:16][CH2:17][CH3:18])([O:13][CH2:14][CH3:15])=[O:12])=[CH:5]\[C:6]([O:8]C)=[O:7]>[OH-].[Na+]>[CH2:22]([O:21][P:19]([CH:10]([P:11]([O:16][CH2:17][CH3:18])([O:13][CH2:14][CH3:15])=[O:12])/[C:4](=[CH:5]/[C:6]([OH:8])=[O:7])/[C:3]([OH:27])=[O:2])([O:24][CH2:25][CH3:26])=[O:20])[CH3:23]参加物
3
実験手順
A solution of 12.7 g of 2-[bis(diethoxyphosphoryl)methyl]maleic acid dimethyl ester in 76.8 ml of 1 N sodium hydroxide is kept under stirring for 96 hours, then the reaction mixture is washed twice with ethyl ether and is brought to pH 8.5 with 37% hydrochloric acid. The mixture is then concentrated to dryness and redissolved in 50 ml of methanol. After filtration of the formed sodium chloride, the solvent is evaporated under reduced pressure. The residue is treated with 125 ml of acetone, to give, after filtration, 11.5 g of the product as disodium salt.
後処理
- washthe reaction mixture is washed twice with ethyl ether
- concentrationThe mixture is then concentrated to dryness