Water → Furo[2,3-c]pyridin-5-ylmethanol

HRID 15330ノート

反応式

HRID 15330 の反応式
C([O:4][CH2:5][C:6]1[CH:7]=[C:8]2[CH:14]=[CH:13][O:12][C:9]2=[CH:10][N:11]=1)(=O)C.O.[OH-].[Na+]>O1CCOCC1>[O:12]1[C:9]2=[CH:10][N:11]=[C:6]([CH2:5][OH:4])[CH:7]=[C:8]2[CH:14]=[CH:13]1

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 22047292HCID 22047292、化合物

生成物 1

HCID 22047174Furo[2,3-c]pyridin-5-ylmethanol収率 70.4%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Also to yield the desired compound: Furo[2,3-c]pyridin-5-ylmethyl acetate (1.15 g, 6 mmol) was dissolved in 1,4-dioxane (30 ml) and water (10 ml) and treated with 2N sodium hydroxide solution (12 ml) and stirred at RT for 18 h. The mixture was then partitioned between ethyl acetate and water, the organic layer was dried and evaporated to dryness to provide the desired compound (0.63 g).

後処理

  1. customThe mixture was then partitioned between ethyl acetate and water
  2. customthe organic layer was dried
  3. customevaporated to dryness

出典と根拠

ORDレコード
ord-adde202e72824f69a5298fe6bf9019ec
出典データセット
uspto-grants-2010_06
特許番号
US07732461B2

反応ノート

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