3-Methylcyclohexanecarboxylic acid → (3-Methylcyclohexyl)methanol
反応式
[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([C:8](O)=[O:9])[CH2:3]1>O1CCCC1.CCOCC>[OH:9][CH2:8][CH:4]1[CH2:5][CH2:6][CH2:7][CH:2]([CH3:1])[CH2:3]1参加物
4
実験手順
To a boran-methyl sulfide complex (1.7 ml, 0.028 mole) in 7 ml tetrahydrofuran, at 0° C., was added dropwise 2 g of 3-methylcyclohexanecarboxylic acid (0.014 mole) in 7 ml tetrahydrofuran. Stirring was continued for one hour. The reaction mixture was diluted with ether and washed with 1N aqueous sodium hydroxide and then with brine. Concentration and distillation gave 1.34 g of the title compound The NMR spectrum showed absorption at 0.54-0.74 (m, 1H), 0.90, 0.93 (s, 3H), 1.17-1.53 (m, 3H), 1.65-1.77 (m, 3H) and 3.39-3.52 (m, 2H).
後処理
- washwashed with 1N aqueous sodium hydroxide
- concentrationConcentration and distillation
出典と根拠
- ORDレコード
- ord-9741e3c8d59d414fb45fe17c1d5dc5aa
- 出典データセット
- uspto-grants-1992_02
- 特許番号
- US05086062
反応ノート
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