Hydroxyamine hydrochloride → 2-Phenylpyrazolo[1,5-a]pyridine-3-carbaldehyde oxime hydrochloride
反応式
[C:1]1([C:7]2[C:15]([CH:16]=O)=[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][N:9]3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:18].[NH2:19][OH:20]>C(O)C>[ClH:18].[C:1]1([C:7]2[C:15]([CH:16]=[N:19][OH:20])=[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][N:9]3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
4
実験手順
A mixture of 2-phenylpyrazolo[1,5-a]pyridine-3-carbaldehyde (0.5 g) and hydroxylamine hydrochloride (0.17 g) in ethanol (5 ml) was refluxed for 1.5 hours and evaporated in vacuo. The residue was triturated with ethyl acetate and recrystallized from a mixture of ethanol and ethyl acetate to give 2-phenylpyrazolo[1,5-a]pyridine-3-carbaldehyde oxime hydrochloride (0.28 g).
後処理
- temperaturewas refluxed for 1.5 hours
- customevaporated in vacuo
- customThe residue was triturated with ethyl acetate
- customrecrystallized from a mixture of ethanol and ethyl acetate
出典と根拠
- ORDレコード
- ord-38344196651441d3bb4c2b59d06cd011
- 出典データセット
- uspto-grants-1992_02
- 特許番号
- US05087629
反応ノート
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