Water → Methyl 3-amino-2-methyl-6-methylthiobenzoate

HRID 1534161

反応式

HRID 1534161 の反応式
O.O.O.O.O.O.O.O.O.[S-2:10].[Na+].[Na+].O.[NH2:14][C:15]1[C:16]([CH3:28])=[C:17]([C:22](SC#N)=[CH:23][CH:24]=1)[C:18]([O:20][CH3:21])=O.[CH3:29]I>C(O)C>[NH2:14][C:15]1[C:16]([CH3:28])=[C:17]([C:22]([CH3:29])=[CH:23][CH:24]=1)[C:18]([O:20][CH3:21])=[S:10]

参加物

6

反応物 4

HCID 962WaterHCID 6328Methyl iodideHCID 73972Sodium sulfide nonahydrateHCID 14801188Methyl 3-amino-2-methyl-6-thiocyanatobenzoate

生成物 1

HCID 54391819Methyl 3-amino-2-methyl-6-methylthiobenzoate収率 104.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution comprising 39.5 g of sodium sulfide nonahydrate and 110 ml of water, a solution comprising 32.9 g of methyl 3-amino-2-methyl-6-thiocyanobenzoate and 300 ml of ethanol, was dropwise added. The mixture was stirred at room temperature for 1.5 hours, and then 24 g of methyl iodide was dropwise added thereto under cooling with ice. The mixture was stirred at room temperature for 2 hours and then concentrated under reduced pressure. A saturated sodium chloride aqueous solution was added thereto, and the mixture was extracted with chloroform. The chloroform layer was dried over anhydrous sodium sulfate, and then the solvent was distilled off to obtain 30.1 g of the desired product. Oily substance.

後処理

  1. additionwas dropwise added
  2. temperatureunder cooling with ice
  3. stirringThe mixture was stirred at room temperature for 2 hours
  4. concentrationconcentrated under reduced pressure
  5. additionA saturated sodium chloride aqueous solution was added
  6. extractionthe mixture was extracted with chloroform
  7. dry with materialThe chloroform layer was dried over anhydrous sodium sulfate
  8. distillationthe solvent was distilled off

出典と根拠

ORDレコード
ord-01748d795d1d4c959bdd937a792b0762
出典データセット
uspto-grants-1992_02
特許番号
US05087724

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