Pyrrolidine → HCID 15165792、化合物

HRID 1534447ノート

反応式

HRID 1534447 の反応式
Cl.CO[C:4](=[O:13])[CH:5]1[CH2:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7][NH:6]1.[NH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1>>[N:14]1([C:4]([CH:5]2[CH2:10][CH2:9][C:8]([CH3:11])([CH3:12])[CH2:7][NH:6]2)=[O:13])[CH2:18][CH2:17][CH2:16][CH2:15]1

参加物

3

反応物 2

HCID 31268PyrrolidineHCID 67791332129769-06-8

生成物 1

HCID 15165792HCID 15165792、化合物

実験手順

4.2 g (23.5 mmoles) of 5,5-dimethyl pipecolic acid methyl ester hydrochloride were added to 40 ml of pyrrolidine kept at 0° C. After the addition, the solution was allowed to reach room temperature and stirring was continued overnight. The reaction mixture was evaporated in vacuo and the residue treated with 30 ml of 40% NaOH, extracted with diethyl ether, dried over sodium sulphate and evaporated in vacuo to dryness to give 3.3 g of the title compound.

後処理

  1. customkept at 0° C
  2. additionAfter the addition
  3. customto reach room temperature
  4. customThe reaction mixture was evaporated in vacuo
  5. additionthe residue treated with 30 ml of 40% NaOH
  6. extractionextracted with diethyl ether
  7. dry with materialdried over sodium sulphate
  8. customevaporated in vacuo to dryness

出典と根拠

ORDレコード
ord-8f11a589412746c98a70e2e1ff6f35e9
出典データセット
uspto-grants-1992_02
特許番号
US05089507

反応ノート

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