Sodium Hydroxide → HCID 10043588、化合物

HRID 1534481ノート

反応式

HRID 1534481 の反応式
[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1Cl)=[CH:13][CH:12]=[CH:11][C:10]=2[CH2:17][O:18]C(=O)C1C=CC=CC=1)(=[O:5])[CH:2]([CH3:4])[CH3:3].[F:27][C:28]1[CH:34]=[CH:33][C:31]([NH2:32])=[C:30]([CH3:35])[CH:29]=1.[OH-].[Na+]>O1CCOCC1.CO>[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:32][C:31]1[CH:33]=[CH:34][C:28]([F:27])=[CH:29][C:30]=1[CH3:35])=[CH:13][CH:12]=[CH:11][C:10]=2[CH2:17][OH:18])(=[O:5])[CH:2]([CH3:3])[CH3:4]

参加物

6

反応物 3

HCID 14798Sodium HydroxideHCID 679824-Fluoro-2-methylanilineHCID 10384366HCID 10384366、化合物

生成物 1

HCID 10043588HCID 10043588、化合物

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

A solution of 3-isobutyryl-4-chloro-8-benzoyloxymethylquinoline (1.84 g, 5 mmol) and 4-fluoro-2-methylaniline (0.78 ml, 7 mmol) in dioxan (25 ml) was heated at reflux for 2 hours, then the solvent evaporated. A solution of sodium hydroxide (0.8 g, 20 mmol) in methanol (50 ml) was added and the mixture stirred at room temperature for 1.5 hours. The resulting precipitate was filtered off and recrystallized from methanol to give (0.48 g, 27%), m.p. 139°-140°.

後処理

  1. temperatureat reflux for 2 hours
  2. customthe solvent evaporated
  3. filtrationThe resulting precipitate was filtered off
  4. customrecrystallized from methanol
  5. customto give (0.48 g, 27%), m.p. 139°-140°

出典と根拠

ORDレコード
ord-113c4a8962444042b7ab0949e43a9e1b
出典データセット
uspto-grants-1992_02
特許番号
US05089504

反応ノート

読み込み中…