Ethyl bromoacetate → HCID 54393850、化合物

反応式

[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]=[CH:12][C:13]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][CH:23]=[C:24]([CH3:26])[CH3:25])=[CH:17][C:16]=2[OH:27])=[O:14])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[K+].Br[CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33]>CC(C)=O>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]=[CH:12][C:13]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][CH:23]=[C:24]([CH3:26])[CH3:25])=[CH:17][C:16]=2[O:27][CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33])=[O:14])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

実験手順

To a solution of 45.1 g of 4-t-butyl-2'-hydroxy-4'-(3-methyl-2-butenyloxy)chalcone in 500 ml of acetone was added 10.6 g of potassium hydroxide, and the mixture was stirred for 5 minutes. Then, 21.5 g of ethyl bromoacetate was added, and the mixture was stirred for 45 minutes. After neutralization with dilute hydrochloric acid, the precipitated solid was collected by filtration, washed with water, dried and recrystallized from ethanol to give 47.6 g of 4-t-butyl-2'-ethoxycarbonylmethoxy-4'-(3-methyl-2-butenyloxy)chalcone as a pale yellow powder.