Hydrogen Bromide → HCID 19908238、化合物
反応式
C1(C)C=CC(S([N:10]2[CH2:18][C:17]3[CH2:16][NH:15][CH2:14][CH2:13][C:12]=3[CH2:11]2)(=O)=O)=CC=1.O.[BrH:21]>C1(O)C=CC=CC=1>[BrH:21].[BrH:21].[C:17]12[CH2:18][NH:10][CH2:11][C:12]=1[CH2:13][CH2:14][NH:15][CH2:16]2参加物
5
実験手順
1.5 g of N8 -(p-toluenesulfonyl)-3,8-diazabicyclo[4.3.0]non-1(6)-ene, prepared in Preparation 8, was suspended in 15 ml of 48% hydrobromic acid and 2 g of phenol, and the reaction mixture was refluxed for 4 hours. After cooling the reaction mixture, 20 ml of water was added. The mixture was washed with chloroform (40 ml×3). The aqueous phase was taken and decolorized by active carbon. The aqueous phase was concentrated under reduced pressure and thus resulting solid was washed with 1:1 methanol-ethylether solvent. 0.9 g of the title compound was obtained (yield 98%).
後処理
- additionwas added
- washThe mixture was washed with chloroform (40 ml×3)
- concentrationThe aqueous phase was concentrated under reduced pressure
- customthus resulting solid
- washwas washed with 1:1 methanol-ethylether solvent
出典と根拠
- ORDレコード
- ord-9bf1777c57564db9a621b1f8f30bbfdc
- 出典データセット
- uspto-grants-1992_02
- 特許番号
- US05091384
反応ノート
読み込み中…