Hexane → 4-(3-t-Butylureidomethyl)-1-aminomethylbenzene

HRID 1535074ノート

反応式

HRID 1535074 の反応式
[C:1]1([CH2:9][NH2:10])[CH:6]=[CH:5][C:4]([CH2:7][NH2:8])=[CH:3][CH:2]=1.CCCCCC.[C:17]([N:21]=[C:22]=[O:23])([CH3:20])([CH3:19])[CH3:18]>C(Cl)Cl>[C:17]([NH:21][C:22](=[O:23])[NH:8][CH2:7][C:4]1[CH:5]=[CH:6][C:1]([CH2:9][NH2:10])=[CH:2][CH:3]=1)([CH3:20])([CH3:19])[CH3:18]

参加物

5

反応物 3

HCID 8058HexaneHCID 62412tert-Butyl isocyanateHCID 683151,4-Benzenedimethanamine

生成物 1

HCID 200967404-(3-t-Butylureidomethyl)-1-aminomethylbenzene収率 42.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2.7 g p-xylylenediamine in 100 ml methylene dichloride, was added slowly with stirring 10 ml of a n-hexan solution containing 990 mg t-butyl isocyanate under ice cooling. Stirring was continued at room temperature for two hours, the solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography, giving 1 g of 4-(3-t-butylureidomethyl)-1-aminomethylbenzene.

後処理

  1. distillationthe solvent was distilled off under reduced pressure
  2. customthe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-721b54c9b9c84ec2bba8d2b907e6c7b8
出典データセット
uspto-grants-1992_02
特許番号
US05091419

反応ノート

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