Bromine → 7-Bromo-2,3-dihydro-1-benzofuran-5-carbaldehyde
反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]=[O:11])=[CH:9][C:4]=2[CH2:3][CH2:2]1.C([O-])(=O)C.[Na+].[Br:17]Br>C(O)(=O)C.S([O-])([O-])(=O)=S.[Na+].[Na+]>[Br:17][C:6]1[C:5]2[O:1][CH2:2][CH2:3][C:4]=2[CH:9]=[C:8]([CH:10]=[O:11])[CH:7]=1参加物
6
実験手順
To a solution of 2,3-dihydro-1-benzofuran-5-carbaldehyde (1.0 g, 6.75 mmol) in glacial acetic acid (8 mL) was added sodium acetate (664 mg, 8.1 mmol) and bromine (0.7 ml, 13.5 mmol) at 10° C. slowly. The reaction was stirred for 2 hours at ambient temperature. The reaction was diluted with a saturated aqueous solution of sodium thiosulfate (10 mL), washed with a saturated aqueous solution of sodium bicarbonate, and then extracted with ethyl acetate. Organics were combined, dried over sodium sulfate and dried in vacuo to give the desired compound (1.4 g, 91%).
後処理
- washwashed with a saturated aqueous solution of sodium bicarbonate
- extractionextracted with ethyl acetate
- dry with materialdried over sodium sulfate
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-fe868f260ebc4113b4e544be8e2d8359
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07732461B2
反応ノート
読み込み中…