2-Chloro-3-nitrobenzoic acid → (2-Chloro-3-nitrophenyl)methanol

HRID 15440

反応式

HRID 15440 の反応式
[Cl:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5]>C1COCC1.O>[Cl:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][OH:5]

参加物

4

反応物 1

HCID 198702-Chloro-3-nitrobenzoic acid

生成物 1

HCID 15132843(2-Chloro-3-nitrophenyl)methanol

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 8028Tetrahydrofuran溶媒

実験手順

10.0 g (49.61 mmol) of 2-chloro-3-nitrobenzoic acid are initially charged in 50 ml of THF. With ice cooling, 104 ml of 1M borane/THF complex are added, and the mixture is stirred at RT overnight. At 0° C., the mixture is carefully hydrolyzed using water. After the evolution of gas has ceased, the mixture is diluted with 500 ml of water and the aqueous phase is extracted three times with in total 500 ml of ethyl acetate. The organic phase is washed with saturated sodium chloride solution and dried over magnesium sulfate. The solvent is then removed under reduced pressure using a rotary evaporator. This gives 9.20 g (98% of theory) of the title compound.

後処理

  1. additionWith ice cooling, 104 ml of 1M borane/THF complex are added
  2. customAt 0° C.
  3. extractionthe aqueous phase is extracted three times with in total 500 ml of ethyl acetate
  4. washThe organic phase is washed with saturated sodium chloride solution
  5. dry with materialdried over magnesium sulfate
  6. customThe solvent is then removed under reduced pressure
  7. customa rotary evaporator

出典と根拠

ORDレコード
ord-5a88544691724218a8b2aa39388aa6b3
出典データセット
uspto-grants-2010_06
特許番号
US07732477B2

関連ノート

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