Tetrahydrofuran → Tert-butyl 4-(5-bromo-2-chloroquinazolin-8-yloxy)piperidine-1-carboxylate

反応式

[Br:34][c:35]1[c:36]2[cH:37][n:38][c:39]([Cl:46])[n:40][c:41]2[c:42]([OH:45])[cH:43][cH:44]1.[C:20]([CH3:21])([CH3:22])([CH3:23])[O:24][C:25](=[O:26])[N:27]1[CH2:28][CH2:29][CH:30]([OH:33])[CH2:31][CH2:32]1.[CH2:47]1[O:48][CH2:49][CH2:50][CH2:51]1.[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[C:20]([CH3:21])([CH3:22])([CH3:23])[O:24][C:25](=[O:26])[N:27]1[CH2:28][CH2:29][CH:30]([O:33][c:42]2[c:41]3[c:36]([c:35]([Br:34])[cH:44][cH:43]2)[cH:37][n:38][c:39]([Cl:46])[n:40]3)[CH2:31][CH2:32]1