Pyridine → 4-fluoro-N-{4-fluoro-3-nitrophenyl}benzenesulfonamide

HRID 15540

反応式

HRID 15540 の反応式
N1C=CC=CC=1.[F:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16].[F:18][C:19]1[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=1>C(Cl)Cl>[F:18][C:19]1[CH:24]=[CH:23][C:22]([S:25]([NH:14][C:11]2[CH:12]=[CH:13][C:8]([F:7])=[C:9]([N+:15]([O-:17])=[O:16])[CH:10]=2)(=[O:27])=[O:26])=[CH:21][CH:20]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 95884-Fluorobenzenesulfonyl chlorideHCID 677684-Fluoro-3-nitroaniline

生成物 1

HCID 7989284-fluoro-N-{4-fluoro-3-nitrophenyl}benzenesulfonamide収率 80.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Pyridine (500 μL, 6.19 mmol) was added to a solution of 4-fluoro-3-nitro-phenylamine (1 g, 6.41 mmol) and 4-fluoro-benzenesulfonyl chloride (1.2 g, 6.19 mmol) in DCM (20 mL) and the reaction was stirred at room temperature overnight. The reaction was then partitioned between water and DCM. The organic layer was washed several times with water and concentrated. Recrystalization from ethanol/water gave 1.57 g of the sub-title compound as tan crystals.

後処理

  1. customThe reaction was then partitioned between water and DCM
  2. washThe organic layer was washed several times with water
  3. concentrationconcentrated
  4. customRecrystalization from ethanol/water

出典と根拠

ORDレコード
ord-aa3756eb13b24f6fa6a98ce382f27114
出典データセット
uspto-grants-2010_06
特許番号
US07732618B2

関連ノート

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