Acetic Acid → [5-(4-Fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

HRID 15541

反応式

HRID 15541 の反応式
[CH:1](=O)[CH2:2][CH2:3][CH3:4].C(O)(=O)C.[C:10]([O:14][C:15](=[O:36])[CH2:16][NH:17][C:18]1[CH:23]=[CH:22][C:21]([NH:24][S:25]([C:28]2[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=2)(=[O:27])=[O:26])=[CH:20][C:19]=1[NH2:35])([CH3:13])([CH3:12])[CH3:11]>CCO>[C:10]([O:14][C:15](=[O:36])[CH2:16][N:17]1[C:18]2[CH:23]=[CH:22][C:21]([NH:24][S:25]([C:28]3[CH:29]=[CH:30][C:31]([F:34])=[CH:32][CH:33]=3)(=[O:27])=[O:26])=[CH:20][C:19]=2[N:35]=[C:1]1[CH2:2][CH2:3][CH3:4])([CH3:13])([CH3:11])[CH3:12]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 261ButanalHCID 67199324[2-Amino-4-(4-fluoro-benzenesulfonylamino)-phenylamino]-acetic acid tert-butyl ester

生成物 1

HCID 67201670[5-(4-Fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
70 °C

実験手順

Butyraldehyde (3.8 mL, 41.8 mmol) and acetic acid (1.4 mL) were added to a solution of [2-amino-4-(4-fluoro-benzenesulfonylamino)-phenylamino]-acetic acid tert-butyl ester (12.5 g, 26.8 mmol) in EtOH (135 mL), and stirred overnight at 70° C. The reaction mixture was cooled to ambient temperature and concentrated under reduced pressure to give the crude sub-titled compound that was used without further purification. MS calculated for C22H26FN3O4S—H: 446, observed: 446.

後処理

  1. temperatureThe reaction mixture was cooled to ambient temperature
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-7210e5014eab4c069930c927dd1fe75b
出典データセット
uspto-grants-2010_06
特許番号
US07732618B2

関連ノート

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