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HRID 15574作成日：2026年10月26日
Sodium Bicarbonate → (4-tert-Butoxycarbonylamino-2-nitro-phenylamino)-acetic acid tert-butyl ester
https://huagongshe.com/reaction/15574
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Glycine tert-butyl ester hydrochloride | HCID 2725036 | — |
| 反応物 | Tert-butyl 4-fluoro-3-nitrophenylcarbamate | HCID 11118665 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | (4-tert-Butoxycarbonylamino-2-nitro-phenylamino)-acetic acid tert-butyl ester | HCID 67201113 | — |
反応手順
Glycine tert-butyl ester hydrochloride (4.1 g, 29.4 mmol) and NaHCO3 (5.1 g, 61.0 mmol) were added to a solution of (4-fluoro-3-nitro-phenyl)-carbamic acid tert-butyl ester (5.2 g, 20.3 mmol) in DMSO (16 mL). The reaction was heated to 65° C. for 5 hours, cooled to room temperature, and partitioned between H2O and EtOAc. The organic layer was washed several times with H2O and concentrated to afford the sub-title compound. MS calculated for C17H25N3O6+H: 368, observed: 368.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07732618B2 |
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| 出典データセット | uspto-grants-2010_06 |
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| ORD ID | ord-d34867f288344e0b81e93b133d1f1951 |
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| 出典メモ | uspto-grants-2010_06 |
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