反应详情

温度

65 °C

Glycine tert-butyl ester hydrochloride (4.1 g, 29.4 mmol) and NaHCO3 (5.1 g, 61.0 mmol) were added to a solution of (4-fluoro-3-nitro-phenyl)-carbamic acid tert-butyl ester (5.2 g, 20.3 mmol) in DMSO (16 mL). The reaction was heated to 65° C. for 5 hours, cooled to room temperature, and partitioned between H2O and EtOAc. The organic layer was washed several times with H2O and concentrated to afford the sub-title compound. MS calculated for C17H25N3O6+H: 368, observed: 368.

1. temperaturecooled to room temperature
2. custompartitioned between H2O and EtOAc
3. washThe organic layer was washed several times with H2O
4. concentrationconcentrated