Acetyl chloride → [5-(Acetyl-benzyl-amino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

HRID 15578

反応式

HRID 15578 の反応式
[C:1](Cl)(=[O:3])[CH3:2].[C:5]([O:9][C:10](=[O:32])[CH2:11][N:12]1[C:16]2[CH:17]=[CH:18][C:19]([NH:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:20][C:15]=2[N:14]=[C:13]1[CH2:29][CH2:30][CH3:31])([CH3:8])([CH3:7])[CH3:6].CCN(C(C)C)C(C)C>CN(C1C=CN=CC=1)C.C(Cl)Cl.Cl>[C:5]([O:9][C:10](=[O:32])[CH2:11][N:12]1[C:16]2[CH:17]=[CH:18][C:19]([N:21]([C:1](=[O:3])[CH3:2])[CH2:22][C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)=[CH:20][C:15]=2[N:14]=[C:13]1[CH2:29][CH2:30][CH3:31])([CH3:8])([CH3:7])[CH3:6]

参加物

7

反応物 3

HCID 6367Acetyl chlorideHCID 81531DiisopropylethylamineHCID 67200053(5-Benzylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester

生成物 1

HCID 67202294[5-(Acetyl-benzyl-amino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

試薬・触媒・溶媒 3

HCID 142844-(Dimethylamino)pyridine触媒HCID 313Hydrochloric Acid溶媒HCID 6344Dichloromethane溶媒

実験手順

Acetyl chloride (25 μL, 0.36 mmol) was added to a solution of (5-benzylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester (45 mg, 0.12 mmol), DIEA (41 μL, 0.24 mmol) and DMAP (15 mg, 0.12 mmol) in CH2Cl2 (1 mL), and stirred overnight at room temperature. The reaction solution was diluted with aqueous HCl (1.0 M) and filtered through an Extrelut column. The Extrelut column was washed with CH2Cl2, and the filtrate was concentrated to afford the subtitle compound that was used without further purification. MS calculated for C25H31N3O3+H: 422, observed: 422.

後処理

  1. filtrationfiltered through an Extrelut column
  2. washThe Extrelut column was washed with CH2Cl2
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-7fe19e508c9a44cc89f2b7f9100f8e99
出典データセット
uspto-grants-2010_06
特許番号
US07732618B2

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