Trifluoroacetic acid → {5-[Benzyl-(4-chloro-benzoyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid

HRID 15591

反応式

HRID 15591 の反応式
C([O:5][C:6](=[O:37])[CH2:7][N:8]1[C:12]2[CH:13]=[CH:14][C:15]([N:17]([CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[C:18](=[O:26])[C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=3)=[CH:16][C:11]=2[N:10]=[C:9]1[CH2:34][CH2:35][CH3:36])(C)(C)C.C(O)(C(F)(F)F)=O>>[CH2:27]([N:17]([C:18](=[O:26])[C:19]1[CH:20]=[CH:21][C:22]([Cl:25])=[CH:23][CH:24]=1)[C:15]1[CH:14]=[CH:13][C:12]2[N:8]([CH2:7][C:6]([OH:37])=[O:5])[C:9]([CH2:34][CH2:35][CH3:36])=[N:10][C:11]=2[CH:16]=1)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 67199607{5-[Benzyl-(4-chloro-benzoyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester

生成物 1

HCID 59342502{5-[Benzyl-(4-chloro-benzoyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid

実験手順

{5-[Benzyl-(4-chloro-benzoyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester (0.12 mmol) was treated with TFA (2 mL) for 2 hours, concentrated, and purified by preparative LCMS to give the title compound. MS calculated for C26H24ClN3O3+H: 462, observed: 462.

後処理

  1. concentrationconcentrated
  2. custompurified by preparative LCMS

出典と根拠

ORDレコード
ord-db0f01f168c2425f892bce4e3e391d32
出典データセット
uspto-grants-2010_06
特許番号
US07732618B2

関連ノート

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