3-Bromopropionic acid → 10-Carboxyethyl-2,7-biscarboethoxyamino-9-phenylphenanthridine

HRID 15609

反応式

HRID 15609 の反応式
[C:1]([NH:6][C:7]1[CH:20]=[CH:19][C:18]2[C:9](=[C:10]3[C:15](=[CH:16][N:17]=2)[C:14]([NH:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:13][C:12]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:11]3)[CH:8]=1)([O:3][CH2:4][CH3:5])=[O:2].Br[CH2:34][CH2:35][C:36]([OH:38])=[O:37]>[N+](C1C=CC=CC=1)([O-])=O>[C:36]([CH2:35][CH2:34][C:11]1[C:10]2[C:15](=[CH:16][N:17]=[C:18]3[C:9]=2[CH:8]=[C:7]([NH:6][C:1]([O:3][CH2:4][CH3:5])=[O:2])[CH:20]=[CH:19]3)[C:14]([NH:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:13][C:12]=1[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)([OH:38])=[O:37]

参加物

4

反応物 2

HCID 115533-Bromopropionic acidHCID 219669182,7-Biscarboethoxyamino-9-phenylphenanthridine

生成物 1

HCID 6869354410-Carboxyethyl-2,7-biscarboethoxyamino-9-phenylphenanthridine

試薬・触媒・溶媒 1

HCID 7416Nitrobenzene溶媒

実験手順

2,7-Biscarboethoxyamino-9-phenylphenanthridine (22-1, 1 equiv.), prepared by the method of Watkins (1952) J. Chem. Soc. 3059, is combined with 3-bromopropionic acid (2.5 equiv.; Aldrich Chemical Co., Milwaukee, Wis.) and is heated in nitrobenzene at 100° C. for 4-6 hours. Following cooling to room temperature the crude product is precipitated by addition of ether. The product 22-2 is isolated by filtration and used directly.

後処理

  1. customis precipitated by addition of ether

出典と根拠

ORDレコード
ord-b6399fa9765c47cd9c2f163023dd8697
出典データセット
uspto-grants-2010_06
特許番号
US07732628B2

関連ノート

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