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3-Bromopropionic acid → 10-Carboxyethyl-2,7-biscarboethoxyamino-9-phenylphenanthridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Bromopropionic acid | HCID 11553 | — |
| 反応物 | 2,7-Biscarboethoxyamino-9-phenylphenanthridine | HCID 21966918 | — |
| 溶媒 | Nitrobenzene | HCID 7416 | — |
| 生成物 | 10-Carboxyethyl-2,7-biscarboethoxyamino-9-phenylphenanthridine | HCID 68693544 | — |
反応手順
2,7-Biscarboethoxyamino-9-phenylphenanthridine (22-1, 1 equiv.), prepared by the method of Watkins (1952) J. Chem. Soc. 3059, is combined with 3-bromopropionic acid (2.5 equiv.; Aldrich Chemical Co., Milwaukee, Wis.) and is heated in nitrobenzene at 100° C. for 4-6 hours. Following cooling to room temperature the crude product is precipitated by addition of ether. The product 22-2 is isolated by filtration and used directly.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732628B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-b6399fa9765c47cd9c2f163023dd8697 |
| 出典メモ | uspto-grants-2010_06 |