Tetrahydrofuran → Methyl 6-chloro-5-[4-[6-(4-fluorophenyl)-2-(3-methylmorpholin-4-yl)pyrimidin-4-yl]-3-methylpiperazin-1-yl]pyrazine-2-carboxylate

反応式

[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][c:7]([Cl:39])[c:8]([N:12]2[CH2:13][CH:14]([CH3:38])[N:15]([c:18]3[n:19][c:20]([N:31]4[CH:32]([CH3:37])[CH2:33][O:34][CH2:35][CH2:36]4)[n:21][c:22](-[c:24]4[cH:25][cH:26][c:27]([F:30])[cH:28][cH:29]4)[cH:23]3)[CH2:16][CH2:17]2)[n:9][c:10]1[Br:11].[H:40][H:41]>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][c:7]([Cl:39])[c:8]([N:12]2[CH2:13][CH:14]([CH3:38])[N:15]([c:18]3[n:19][c:20]([N:31]4[CH:32]([CH3:37])[CH2:33][O:34][CH2:35][CH2:36]4)[n:21][c:22](-[c:24]4[cH:25][cH:26][c:27]([F:30])[cH:28][cH:29]4)[cH:23]3)[CH2:16][CH2:17]2)[n:9][cH:10]1