Hydrochloric Acid → 6-Methyltetrazolo[1,5-a]quinoxaline

HRID 1576010ノート

反応式

HRID 1576010 の反応式
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[CH3:12])[N:3]=1.Cl.[N-:14]=[N+:15]=[N-:16].[Na+]>C(O)C>[CH3:12][C:8]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:9]=1[N:10]=[CH:11][C:2]1[N:3]2[N:14]=[N:15][N:16]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 33557Sodium AzideHCID 126864052-Chloro-5-methylquinoxaline

生成物 1

HCID 215049236-Methyltetrazolo[1,5-a]quinoxaline収率 91%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution was made of 0.5 g. of 2-chloro-5-methylquinoxaline, 10 ml. of 0.1N HCl and 0.6 g. of sodium azide in 35 ml. of denatured ethanol. The reaction mixture was stirred for 6 hours at reflux temperature. When the mixture was allowed to cool, the product, 6-methyltetrazolo[1,5-a]quinoxaline, crystallized in 91 percent yield and was separated by filtration. The product had a melting point of 160°-62°C., and was identified by nuclear magnetic resonance analysis and elemental microanalysis, the results of which were as follows.

後処理

  1. temperatureat reflux temperature
  2. temperatureto cool
  3. customthe product, 6-methyltetrazolo[1,5-a]quinoxaline, crystallized in 91 percent yield
  4. customwas separated by filtration
  5. customthe results of which

出典と根拠

ORDレコード
ord-28a2ad85ba7e4627915a9bf9ab8d065e
出典データセット
uspto-grants-1976_09
特許番号
US03979387

反応ノート

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