Thionyl Chloride → HCID 21823971、化合物

反応式

[CH2:1]([NH:5][C:6]1[C:11]([C:12](O)=[O:13])=[CH:10][N:9]=[C:8]2[N:15]([CH2:18][CH3:19])[N:16]=[CH:17][C:7]=12)[CH2:2][CH2:3][CH3:4].S(Cl)([Cl:22])=O>>[CH2:1]([NH:5][C:6]1[C:11]([C:12]([Cl:22])=[O:13])=[CH:10][N:9]=[C:8]2[N:15]([CH2:18][CH3:19])[N:16]=[CH:17][C:7]=12)[CH2:2][CH2:3][CH3:4]

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 21823970HCID 21823970、化合物

生成物 1

HCID 21823971HCID 21823971、化合物

実験手順

26.2 g of 4-butylamino-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid (0.1 mol) and 100 ml of thionyl chloride are refluxed for 4 hours. The thionyl chloride is removed by means of a water aspirator. The residue, containing the crude 4-butyl-amino-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride, is recrystallized from benzene, and has a melting point of 142°-145°. Yield 23.5 g = 84% of theory.

後処理

customThe thionyl chloride is removed by means of a water aspirator
additionThe residue, containing the crude 4-butyl-amino-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride
customis recrystallized from benzene

出典と根拠

ORDレコード: ord-77c54833375d41ef858a129a8572d6d4
出典データセット: uspto-grants-1976_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US03979399

反応ノート

読み込み中…

参加物