Hydrazine hydrate (1:1) → cis-5-(4-Chlorophenylsulfonyl)-4,6-dimethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine
反応式
Cl[C:2]1C=CC(S(N2[C@H](C)CC(=O)C[C@@H]2C)(=O)=O)=CC=1.CN(C(OC)OC)C.O.NN.[Cl:31][C:32]1[CH:37]=[CH:36][C:35]([S:38]([N:41]2[CH2:46][CH2:45]C(=O)[CH2:43][CH:42]2[C:48]2[CH:49]=[N:50]C=[N:52][CH:53]=2)(=[O:40])=[O:39])=[CH:34][CH:33]=1>>[Cl:31][C:32]1[CH:33]=[CH:34][C:35]([S:38]([N:41]2[C@H:46]([CH3:45])[CH2:2][C:53]3[NH:52][N:50]=[CH:49][C:48]=3[C@@H:42]2[CH3:43])(=[O:39])=[O:40])=[CH:36][CH:37]=1参加物
5
反応物 4
生成物 1
実験手順
cis-1-(4-Chlorophenylsulfonyl)-2,6-dimethylpiperidin-4-one (92) was treated with DMF-DMA followed by hydrazine hydrate as described for compound 71 in Example 4.
出典と根拠
- ORDレコード
- ord-1e83bddc5d5d45a3a394b31a1ddd21f9
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07732609B2
反応ノート
読み込み中…