4-Piperidinol, 1-(1H-indol-3-yloxoacetyl)-4-phenyl- → HCID 12589402、化合物

HRID 1576485ノート

反応式

HRID 1576485 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10](=O)[C:11]([N:13]2[CH2:18][CH2:17][C:16]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)([OH:19])[CH2:15][CH2:14]2)=O)=[CH:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[OH:19][C:16]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:15][CH2:14][N:13]([CH2:11][CH2:10][C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][CH:2]=2)[CH2:18][CH2:17]1

参加物

4

反応物 2

HCID 2055944-Piperidinol, 1-(1H-indol-3-yloxoacetyl)-4-phenyl-HCID 21226445Aluminium lithium hydride

生成物 1

HCID 12589402HCID 12589402、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of 17.0 g. (0.049 mole) of 1-(indol-3-ylglyoxyloyl)-4-phenyl-4-piperidinol in 100 ml. of tetrahydrofuran was reduced in the usual way with 7.4 g. (0.195 mole) of lithium aluminum hydride in 200 ml. of tetrahydrofuran. After the usual workup 11.6 g. of oil was obtained which was crystallized from benzene-isooctane yielding 8.6 g. (55%) of product which melted at 133°-137° C. Another recrystallization from benzene raised the melting point to 137°-139° C. The analytical sample melted at 137°-139° C.

後処理

  1. customof oil was obtained which
  2. customwas crystallized from benzene-isooctane yielding 8.6 g
  3. customAnother recrystallization from benzene
  4. temperatureraised the melting point to 137°-139° C

出典と根拠

ORDレコード
ord-8a2e53330eaf4964a3f569b999ddd63b
出典データセット
uspto-grants-1976_09
特許番号
USRE028973

反応ノート

読み込み中…