Water → HCID 21412112、化合物

HRID 1576605

反応式

HRID 1576605 の反応式
I[CH2:2][CH2:3][CH2:4][CH:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[CH:9]=[CH:8][C:7]2[CH:16]=[CH:17][CH:18]=[CH:19][C:6]1=2.CN(C)C=O.[C:25]1(=[O:35])[NH:29][C:28](=[O:30])[C:27]2=[CH:31][CH:32]=[CH:33][CH:34]=[C:26]12.[K].O>C(Cl)(Cl)Cl>[C:25]1(=[O:35])[N:29]([CH2:2][CH2:3][CH2:4][CH:5]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[CH:9]=[CH:8][C:7]3[CH:16]=[CH:17][CH:18]=[CH:19][C:6]2=3)[C:28](=[O:30])[C:27]2=[CH:31][CH:32]=[CH:33][CH:34]=[C:26]12

参加物

6

反応物 4

HCID 962WaterHCID 6228DimethylformamideHCID 233288685-(3-iodopropyl)-5H-dibenzo[a,d]cyclohepteneHCID 24194345Phthalimide potassium salt

生成物 1

HCID 21412112HCID 21412112、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

5-(3-Iodopropyl)-5H-dibenzo[a,d]cycloheptene, 1.8 g. (0.005 mole), is dissolved in 10 ml. of dimethylformamide. The solution is stirred while 930 mg. (0.0051 mole) of potassium phthalimide is added. When the addition is complete, the mixture is heated to 85°-90°C. for 40 minutes, then cooled, diluted with chloroform and poured into water. The chloroform layer is separated and the aqueous layer extracted further with chloroform. Evaporation of the chloroform gives the product as an oily crystalline solid. Several recrystallizations from isopropyl alcohol gave product, m.p. 125.5°-131.5°C.

後処理

  1. dissolution(0.005 mole), is dissolved in 10 ml
  2. additionWhen the addition
  3. temperaturethe mixture is heated to 85°-90°C. for 40 minutes
  4. temperaturecooled
  5. customThe chloroform layer is separated
  6. extractionthe aqueous layer extracted further with chloroform
  7. customEvaporation of the chloroform

出典と根拠

ORDレコード
ord-35684be8265d446c83c7863be28e82e8
出典データセット
uspto-grants-1976_09
特許番号
US03981917

関連ノート

読み込み中…