Methyl chloroformate → N-methoxycarbonylphthalimide

HRID 1576735ノート

反応式

HRID 1576735 の反応式
[C:1]1(=[O:11])[NH:5][C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[K].[CH3:13][O:14][C:15](Cl)=[O:16]>>[CH3:13][O:14][C:15]([N:5]1[C:1](=[O:11])[C:2]2=[CH:10][CH:9]=[CH:8][CH:7]=[C:3]2[C:4]1=[O:6])=[O:16]

参加物

3

反応物 2

HCID 6586Methyl chloroformateHCID 24194345Phthalimide potassium salt

生成物 1

HCID 5043525N-methoxycarbonylphthalimide

実験手順

A suspension comprising 25 millimoles of potassium phthalimide and 20 ml of methylchloroformate is refluxed for a period of approximately 31/2 hours. Upon completion of refluxing, the reaction mediuim is cooled, filtered, with insolubles being removed continuously by treatment with hot acteone until only potassium chloride remains. The desired product m.p. 184° - 184.5°C., is obtained from the acetone.

後処理

  1. temperatureis refluxed for a period of approximately 31/2 hours
  2. temperatureUpon completion of refluxing
  3. temperaturethe reaction mediuim is cooled
  4. filtrationfiltered, with insolubles
  5. custombeing removed continuously by treatment with hot acteone until only potassium chloride

出典と根拠

ORDレコード
ord-3cb2362fdde641d6b9ac79938eaaa5ef
出典データセット
uspto-grants-1976_09
特許番号
US03982891

反応ノート

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