Phenylethanolamine → alpha-(((4,5-Dihydro-1H-imidazol-2-yl)amino)methyl)benzyl alcohol

HRID 1576839

反応式

HRID 1576839 の反応式
[OH:1][CH:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:3][NH2:4].N([C:15]1[NH:16][CH2:17][CH2:18][N:19]=1)[N+]([O-])=O.C1(C)C(C)=CC=CC=1>CC(C)=O>[OH:1][CH:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:3][NH:4][C:15]1[NH:19][CH2:18][CH2:17][N:16]=1

参加物

5

反応物 3

HCID 1000PhenylethanolamineHCID 7237O-XyleneHCID 4100422-Nitroamino-2-imidazoline

生成物 1

HCID 103775alpha-(((4,5-Dihydro-1H-imidazol-2-yl)amino)methyl)benzyl alcohol

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
160 °C

実験手順

A mixture of 15.8 parts β-hydroxy-phenethyl-amine, 13 parts 2-nitramino-2-imidazoline and 8 parts xylene is stirred and heated for 30 minutes at 160°C. (oil-bath). After cooling the reaction mixture to a temperature of about 70°C., there are added 40 parts acetone. The whole is filtered warm and after cooling the filtrate to room temperature, the precipicated product is filtered off and dried, yielding 2-(β-hydroxy-phenethyl-amino)-2-imidazoline; m.p. 147°-149°C.

後処理

  1. temperatureAfter cooling the reaction mixture to a temperature of about 70°C., there
  2. filtrationThe whole is filtered
  3. temperaturewarm
  4. temperatureafter cooling the filtrate to room temperature
  5. filtrationthe precipicated product is filtered off
  6. customdried

出典と根拠

ORDレコード
ord-89c90c3b4a1241ecba9222bfc6b6ec7a
出典データセット
uspto-grants-1976_09
特許番号
US03983133

関連ノート

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