Benzene → p-Fluoro-alpha-(2-imidazolin-2-ylaminomethyl)benzyl alcohol

HRID 1576844

反応式

HRID 1576844 の反応式
[NH2:1][CH2:2][CH:3]([OH:11])[C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][CH:5]=1.C1(C)C(C)=CC=CC=1.N([C:24]1[NH:25][CH2:26][CH2:27][N:28]=1)[N+]([O-])=O.C1C=CC=CC=1>CC(C)=O>[F:10][C:7]1[CH:8]=[CH:9][C:4]([CH:3]([OH:11])[CH2:2][NH:1][C:24]2[NH:28][CH2:27][CH2:26][N:25]=2)=[CH:5][CH:6]=1

参加物

6

反応物 4

HCID 241BenzeneHCID 7237O-XyleneHCID 98272-Amino-1-(4-fluorophenyl)ethan-1-olHCID 4100422-Nitroamino-2-imidazoline

生成物 1

HCID 54097200p-Fluoro-alpha-(2-imidazolin-2-ylaminomethyl)benzyl alcohol

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
160 °C

実験手順

To a solution of 6.5 parts of α-(aminomethyl)-p-fluorobenzyl alcohol in 8 parts of xylene are added 5.2 parts of 2-(nitramino)-2-imidazoline. The mixture is heated in an oil-bath to about 160°C. till gas-evolution is ceased (about 15 minutes). The reaction mixture is cooled and treated with benzene and acetone. The product is sucked off and crystallized from 4-methyl-2-pentanone, yielding p-fluoro-α-(2-imidazolin-2-ylaminomethyl)benzyl alcohol; m.p. 153.4°C.

後処理

  1. custom(about 15 minutes)
  2. temperatureThe reaction mixture is cooled
  3. customcrystallized from 4-methyl-2-pentanone

出典と根拠

ORDレコード
ord-5e07924bcc1c4a1786b6b7b727016d36
出典データセット
uspto-grants-1976_09
特許番号
US03983133

関連ノート

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