4-Chloro-2-toluidine → 3-(2-Methyl-4-chloroanilino)propionaldehyde
反応式
[CH3:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:3]=1[NH2:4].Br[CH:11]([CH3:14])[CH:12]=[O:13].C(=O)([O-])[O-].[Na+].[Na+]>>[CH3:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:3]=1[NH:4][CH2:14][CH2:11][CH:12]=[O:13]参加物
4
反応条件
- 温度
- 150 °C
実験手順
2-Methyl-4-chloroaniline (1.0 mole), the diethyl acetal of 2-bromopropionaldehyde (1.0 mole) and sodium carbonate (1.0 mole) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The mixture is heated at a temperature of about 150°C for a period of about 24 hours. After this time the reaction mixture is cooled to room temperature and is filtered. The filtrate is then distilled under vacuum to yield the desired product the diethyl acetal of 3-(2-methyl-4-chloroanilino)propionaldehyde as the residue.
後処理
- customequipped with a mechanical stirrer
- temperaturethermometer and reflux condenser
- temperatureAfter this time the reaction mixture is cooled to room temperature
- filtrationis filtered
- distillationThe filtrate is then distilled under vacuum
出典と根拠
- ORDレコード
- ord-f33261b76033415585048cf73267c0af
- 出典データセット
- uspto-grants-1976_09
- 特許番号
- US03983174
反応ノート
読み込み中…