2-Thiophenecarbonyl chloride → HCID 21510384、化合物
反応式
Cl.[OH:2][C:3]1[C:4]([CH3:11])=[N:5][CH:6]=[C:7]([CH2:9][OH:10])[CH:8]=1.[C:12]1([C:17](Cl)=[O:18])[S:16][CH:15]=[CH:14][CH:13]=1>N1C=CC=CC=1>[OH:10][CH2:9][C:7]1[CH:8]=[C:3]([O:2][C:17](=[O:18])[C:12]2[S:16][CH:15]=[CH:14][CH:13]=2)[C:4]([CH3:11])=[N:5][CH:6]=1参加物
4
実験手順
To a solution of 0.9 g of 3-hydroxy-5-hydroxymethyl-2-methylpyridine hydrochloride in 5 ml. of pyridine was added dropwise 0.7 g. of 2-thenoyl chloride under cooling. The resulting mixture was stirred overnight, poured into ice-water and then extracted with chloroform. The extract was washed with water, dried over anhydrous sodium sulfate and the solvent was distilled off to give an oily substance. This substance was purified by silica gel chromatography to give 0.75 g. of the desired product. m.p. 59° - 61°C.