Acetic Acid → HCID 20519163、化合物

HRID 1577280ノート

反応式

HRID 1577280 の反応式
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[C:4]([C:13]([NH:15][CH2:16][CH2:17][CH2:18][CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]([CH2:30][CH3:31])([CH3:29])[CH3:28])=[CH:23][C:22]=2[C:32]([CH2:35][CH3:36])([CH3:34])[CH3:33])=[O:14])[CH:3]=1.[CH3:37][O:38][C:39](=[O:53])[C:40]1[CH:45]=[CH:44][C:43]([S:46](Cl)(=[O:48])=[O:47])=[CH:42][C:41]=1[N+:50]([O-:52])=[O:51].N1C=CC=CC=1.C(O)(=O)C>C(Cl)Cl>[C:32]([C:22]1[CH:23]=[C:24]([C:27]([CH2:30][CH3:31])([CH3:28])[CH3:29])[CH:25]=[CH:26][C:21]=1[O:20][CH2:19][CH2:18][CH2:17][CH2:16][NH:15][C:13]([C:4]1[CH:3]=[C:2]([NH:1][S:46]([C:43]2[CH:44]=[CH:45][C:40]([C:39]([O:38][CH3:37])=[O:53])=[C:41]([N+:50]([O-:52])=[O:51])[CH:42]=2)(=[O:47])=[O:48])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]=1[OH:12])=[O:14])([CH2:35][CH3:36])([CH3:34])[CH3:33]

参加物

6

反応物 4

HCID 176Acetic AcidHCID 1049PyridineHCID 30848622-Naphthalenecarboxamide, 4-amino-N-[4-[2,4-bis(1,1-dimethylpropyl)phenoxy]butyl]-1-hydroxy-HCID 20519165Methyl 4-(chlorosulfonyl)-2-nitrobenzoate

生成物 1

HCID 20519163HCID 20519163、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

4-Amino-N-[4-(2,4-di-t-pentylphenoxy)butyl]-1-hydroxy-2-naphthamide (11.7 g, 23.8 mmoles) was dissolved in methylene chloride (300 ml) under nitrogen and reacted with intermediate (B) (6.7 g, 25.2 mmoles) in the presence of pyridine (2.0 g). After 5 hours of stirring at room temperature, acetic acid (2 ml) was added and the mixture was evaporated to dryness. Trituration of the residue gave a solid which was collected by filtration and recrystallized from ethanol; yield, 8.0 g (46.8 percent).

後処理

  1. customthe mixture was evaporated to dryness
  2. customTrituration of the residue gave a solid which
  3. filtrationwas collected by filtration
  4. customrecrystallized from ethanol
  5. customyield

出典と根拠

ORDレコード
ord-3f5b0f389a104bf6a15da13da3c12bcf
出典データセット
uspto-grants-1981_09
特許番号
US04287292

反応ノート

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