Hydrochloric Acid → 2-Hydroxynonanedioic acid

HRID 1577697ノート

反応式

HRID 1577697 の反応式
Br[CH:2]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15]C)=[O:14])[C:3]([O:5]C)=[O:4].C(=O)([O-])[O-:18].[Na+].[Na+].Cl.[Cl-].[Na+]>O>[OH:18][CH:2]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])[C:3]([OH:5])=[O:4]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 10340Sodium CarbonateHCID 12760707Dimethyl 2-bromononanedioate

生成物 1

HCID 127607082-Hydroxynonanedioic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A stirred mixture of 295 g. of dimethyl 2-bromononanedioate, [Acta. Chim. Acad. Sci. Hung., 46, 85(1965)], 371 g. of anhydrous sodium carbonate, and 3 liters of water is heated at reflux for 22 hours. The solution which forms is cooled and acidified with 600 ml. of 12 N hydrochloric acid. The mixture is saturated with sodium chloride and extracted with ethyl acetate. The extract is washed with brine, dried over magnesium sulfate, and concentrated to give 184 g. of white solid, m.p. 86°-92° C.

後処理

  1. additionA stirred mixture of 295 g
  2. temperatureat reflux for 22 hours
  3. temperatureThe solution which forms is cooled
  4. extractionextracted with ethyl acetate
  5. washThe extract is washed with brine
  6. dry with materialdried over magnesium sulfate
  7. concentrationconcentrated
  8. customto give 184 g

出典と根拠

ORDレコード
ord-43b3015876924c10ad4c9eacd3ec285b
出典データセット
uspto-grants-1981_09
特許番号
US04288632

反応ノート

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