Hydrochloric Acid → 2-Hydroxynonanedioic acid
反応式
Br[CH:2]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15]C)=[O:14])[C:3]([O:5]C)=[O:4].C(=O)([O-])[O-:18].[Na+].[Na+].Cl.[Cl-].[Na+]>O>[OH:18][CH:2]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])[C:3]([OH:5])=[O:4]参加物
6
実験手順
A stirred mixture of 295 g. of dimethyl 2-bromononanedioate, [Acta. Chim. Acad. Sci. Hung., 46, 85 (1965)], 371 g. of anhydrous sodium carbonate, and 3 liters of water is heated at reflux for 22 hours. The solution which forms is cooled and acidified with 600 ml. of 12 N hydrochloric acid. The mixture is saturated with sodium chloride and extracted with ethyl acetate. The extract is washed with brine, dried over magnesium sulfate, and concentrated to give 184 g. of white solid, m.p. 86°-92° C.
後処理
- additionA stirred mixture of 295 g
- temperatureat reflux for 22 hours
- temperatureThe solution which forms is cooled
- extractionextracted with ethyl acetate
- washThe extract is washed with brine
- dry with materialdried over magnesium sulfate
- concentrationconcentrated
- customto give 184 g
出典と根拠
- ORDレコード
- ord-5c5e5202ac7a4ad98783b20bf08461c4
- 出典データセット
- uspto-grants-1981_09
- 特許番号
- US04288630
反応ノート
読み込み中…