Thionyl Chloride → 4-(Pyrid-4-yl)butyroyl chloride hydrochloride

HRID 1577847ノート

反応式

HRID 1577847 の反応式
[ClH:1].[N:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=O)=[CH:4][CH:3]=1.S(Cl)([Cl:16])=O>ClC(Cl)C.CN(C)C=O>[ClH:16].[N:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([Cl:1])=[O:13])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 24386Thionyl ChlorideHCID 467359454-Pyridin-4-YL-butyric acid hydrochloride

生成物 1

HCID 205699404-(Pyrid-4-yl)butyroyl chloride hydrochloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 63651,1-Dichloroethane溶媒

実験手順

4-(Pyrid-4-yl)butyric acid hydrochloride (ca. 35 g) in dichloroethane (250 ml) and dimethylformamide (0.5 ml) was treated with thionyl chloride (100 ml). The vigorous exothermic reaction was allowed to subside and then the mixture was heated under reflux for 10 minutes, followed by evaporation to dryness in vacuo to give crude 4-(pyrid-4-yl)butyroyl chloride hydrochloride.

後処理

  1. customThe vigorous exothermic reaction
  2. temperaturethe mixture was heated
  3. temperatureunder reflux for 10 minutes
  4. customfollowed by evaporation to dryness in vacuo

出典と根拠

ORDレコード
ord-a207383eb217417cae2155479e9acfab
出典データセット
uspto-grants-1981_09
特許番号
US04289772

反応ノート

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