Methyl iodide → HCID 178503870、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]([NH:12][C:13](=[O:15])[CH3:14])=[S:11].[OH-].[K+].[CH3:18]I>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10](=[N:12][C:13](=[O:15])[CH3:14])[S:11][CH3:18]参加物
5
実験手順
26.3 g (0.1 M) of N-(2,6-dichlorophenyl)-N'-acetylthiourea, 8.1 g (0.12 M as 100%) of potassium hydroxide, 7.7 ml (0.12 M) of methyliodide and 250 ml of ethanol are mixed and are heated in a water bath at 50°-60° for 5 hours. The ethanol is distilled off. The residue in the flask is washed with water and filtered. After recrystallization from isopropanol 14.0 g (50.5 % of the theoretical yield) of N-(2,6 -dichlorophenyl)-N'-acetyl-S-methylisothiourea are isolated.
後処理
- temperatureare heated in a water bath at 50°-60° for 5 hours
- distillationThe ethanol is distilled off
- washThe residue in the flask is washed with water
- filtrationfiltered
- customAfter recrystallization from isopropanol 14.0 g (50.5 % of the
出典と根拠
- ORDレコード
- ord-2219f054f25645879382cedd89156cd6
- 出典データセット
- uspto-grants-1981_09
- 特許番号
- US04290971
反応ノート
読み込み中…