2-Methylquinolin-5-yl trifluoromethanesulfonate → 7-Chloro-2-methyl-5-piperazin-1-ylquinoline
反応式
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH3:12])=[N:9]2)=[C:4](O)[CH:3]=1.FC(F)(F)S(OC1C=CC=C2C=1C=CC(C)=N2)(=O)=O.CC1C=CC2C(=CC=CC=2[N:44]2[CH2:49][CH2:48][N:47](C(OC(C)(C)C)=O)[CH2:46][CH2:45]2)N=1.CC1C=CC2C(=CC=CC=2N2CCNCC2)N=1>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH3:12])=[N:9]2)=[C:4]([N:44]2[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]2)[CH:3]=1参加物
5
実験手順
The title compound was prepared from 7-chloro-5-hydroxy-2-methylquinoline (WO/0234754) using similar procedures to descriptions D1, D2 and D3.
出典と根拠
- ORDレコード
- ord-13294da39753479ab5e595d8d3b068b3
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07732600B2
反応ノート
読み込み中…