Pyrrolidine → HCID 13354170、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1Cl)[N:8]([CH2:13][CH3:14])[CH:7]=[C:6]([C:15]([OH:17])=[O:16])[C:5]2=[O:18].[NH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1>CS(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1)[N:8]([CH2:13][CH3:14])[CH:7]=[C:6]([C:15]([OH:17])=[O:16])[C:5]2=[O:18]参加物
4
反応条件
- 温度
- 110 °C
実験手順
A mixture of 6,7-dichloro-1-ethyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (4.3 g), pyrrolidine (10 cm3) and DMSO (45 cm3) was heated for 2 hours at 110° C. Part of the reaction product precipitated during the reaction. After cooling, it was filtered off and recrystallised from DMF (50 cm3). 3 g of 6-chloro-1-ethyl-4-oxo-7-pyrrolidino-1,4-dihydro-quinoline-3-carboxylic acid, m.p. 325° C., were obtained.