Ethanol → 1,3,5-Trimethyl-6-(2-(2-diethylaminoethoxy)phenyl)-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-one

HRID 1578805ノート

反応式

HRID 1578805 の反応式
[CH3:1][N:2]1[C:6]([C:7](Cl)=[O:8])=[C:5]([N+:10]([O-])=O)[C:4]([CH3:13])=[N:3]1.[NH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[OH:21].[N+]([NH-])([O-])=O.N[NH-].N1C2C=NC=N[C:31]=2[C:30](=O)N=1.Cl.[CH2:39]([N:41]([CH2:44][CH2:45]Cl)[CH2:42][CH3:43])[CH3:40].C(O)C.[O-]CC.[Na+]>C(O)(=O)C>[CH3:1][N:2]1[C:6]2[C:7](=[O:8])[N:14]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[O:21][CH2:40][CH2:39][N:41]([CH2:44][CH3:45])[CH2:42][CH3:43])[C:30]([CH3:31])=[N:10][C:5]=2[C:4]([CH3:13])=[N:3]1

参加物

10

反応物 8

HCID 702EthanolHCID 58012-AminophenolHCID 133631-Chloro-2-(diethylamine)ethane hydrochlorideHCID 168365Hydrazide (H3N21-)2 回HCID 2723922Sodium ethoxideHCID 103756241,3-Dimethyl-4-nitro-5-pyrazolecarboxylic acid chlorideHCID 53630237PyrazolopyrimidinoneHCID 178514247HCID 178514247、化合物

生成物 1

HCID 215585381,3,5-Trimethyl-6-(2-(2-diethylaminoethoxy)phenyl)-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-one

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

1,3-Dimethyl-4-nitro-5-pyrazolecarboxylic acid chloride is reacted with an equimolar quantity of o-aminophenol and the resulting nitroamide is catalytically reduced to the amino amide. Following the method of Example 2, the amino amide is cyclized with acetic acid in an autoclave and the resulting pyrazolopyrimidone is treated with an equimolar amount of diethylaminoethylchloride hydrochloride in absolute ethanol containing two equivalents of sodium ethoxide. 1,3,5-Trimethyl-6-(2-(2-diethylaminoethoxy)phenyl)-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-one is obtained from the reaction mixture.

出典と根拠

ORDレコード
ord-3911455a917d407eb578c6f2894bade6
出典データセット
uspto-grants-1976_02
特許番号
US03939161

反応ノート

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