Ethanethiol → HCID 54553130、化合物

HRID 1578855ノート

反応式

HRID 1578855 の反応式
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[N:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[OH-].[Na+].[CH2:15]([SH:17])[CH3:16]>CC(C)=O.O>[Cl:1][C:2]1[N:3]=[C:4]([S:17][CH2:15][CH3:16])[C:5]2[N:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1

参加物

6

反応物 3

HCID 6343EthanethiolHCID 14798Sodium HydroxideHCID 119580532,4-DICHLOROPYRIDO[3,2-D]PYRIMIDINE

生成物 1

HCID 54553130HCID 54553130、化合物収率 65%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 962Water溶媒2 回

実験手順

A suspension of 15 gm (0.075 mol) of 2,4-dichloropyrido[3,2-d]pyrimidine in 100 ml of acetone at -40°C was admixed with a solution of 3.2 gm (0.08 mol) of sodium hydroxide and 4.9 gm (5.8 ml) of ethylmercaptan in 25 ml of water, and the mixture was stirred for two hours at room temperature. Thereafter, 200 ml of water were added to the reaction mixture, and the precipitate formed thereby was collected and recrystallized from petroleum ether, yielding 11.0 gm (65% of theory) of 2-chloro-4-ethylmercapto-pyrido[3,2-d]pyrimidine, m.p. 101°-103°C.

後処理

  1. customthe precipitate formed
  2. customthereby was collected
  3. customrecrystallized from petroleum ether

出典と根拠

ORDレコード
ord-a75d9329604c4255b2c6c06a9e159a1c
出典データセット
uspto-grants-1976_02
特許番号
US03939268

反応ノート

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